Open AccessExosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis
Author(s) -
Ting Liu,
Mei Liu,
Chunwen Zheng,
Daoyan Zhang,
Mingbao Li,
Lu Zhang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s323671
Subject(s) - microvesicles , cancer research , apoptosis , stromal cell , mdm2 , competing endogenous rna , biology , downregulation and upregulation , cell growth , microbiology and biotechnology , microrna , long non coding rna , gene , genetics
Exosomes secreted by peritoneal macrophages (pMφ) are deeply involved in the development of endometriosis (EMs). Exosomes can mediate cell-to-cell communication by transferring biological molecules. This study aimed to explore the effect and mechanism of exosomal long non-coding RNA (lncRNA) CHL1-AS1 derived from pMφ on EMs.