Open AccessLayered Double Hydroxide Modified with Deoxycholic and Hyaluronic Acids for Efficient Oral Insulin Absorption
Author(s) -
Xia Huang,
Shangcong Han,
Zuxian Chen,
Lei Zhao,
Changduo Wang,
Qingyang Guo,
Yanfeng Li,
Yong Sun
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s323381
Subject(s) - paracellular transport , hyaluronic acid , insulin , chemistry , deoxycholic acid , bile acid , glycocholic acid , tight junction , absorption (acoustics) , cholic acid , biochemistry , materials science , biology , membrane , endocrinology , permeability (electromagnetism) , composite material , genetics
This study aimed to construct a layered double hydroxide (LDH) nanoparticle delivery system that was modified by deoxycholic acid (DCA) and hyaluronic acid (HA) to increase the bioavailability of oral insulin.