Open AccessExtracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
Author(s) -
Li Yu,
Qing Xiao,
Jie Tang,
Li Li
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s322356
Subject(s) - extracellular vesicles , skin cancer , human skin , clinical trial , vesicle , skin aging , medicine , extracellular vesicle , microvesicles , biology , cancer , pathology , microbiology and biotechnology , dermatology , microrna , biochemistry , genetics , membrane , gene
Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.