Open AccessLevofloxacin-Loaded Nanosonosensitizer as a Highly Efficient Therapy for Bacillus Calmette-Guérin Infections Based on Bacteria-Specific Labeling and Sonotheranostic Strategy
Author(s) -
Gangjing Li,
LI Jian-hu,
Yuru Hou,
Shuang Xie,
Jieru Xu,
Min Yang,
Dairong Li
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s321631
Subject(s) - levofloxacin , mycobacterium tuberculosis , in vivo , bacteria , pharmacology , plga , ofloxacin , sonication , medicine , microbiology and biotechnology , antibiotics , tuberculosis , in vitro , chemistry , ciprofloxacin , biology , pathology , biochemistry , genetics , radiology
The rapid emergence of multidrug-resistant Mycobacterium tuberculosis ( MTB ) poses a significant challenge to the treatment of tuberculosis (TB). Sonodynamic antibacterial chemotherapy (SACT) combined with sonosensitizer-loaded nanoparticles with targeted therapeutic function is highly expected to eliminate bacteria without fear of drug resistance. This study aimed to investigate the antibacterial effect and underlying mechanism of levofloxacin-loaded nanosonosensitizer with targeted therapeutic function against Bacillus Calmette-Guérin bacteria ( BCG , an MTB model).