Open AccessDual Targeting of Endoplasmic Reticulum by Redox-Deubiquitination Regulation for Cancer Therapy
Author(s) -
Bao-Jun Cai,
Mengfei Hou,
Shijun Zhang,
Xiaoyang Zheng,
Jiwei Huang,
Jingxing Yang,
Yueming Wang,
Xiushan Cai,
Shao Wei Xie,
Chunfu Zhang,
Yiran Huang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s321612
Subject(s) - endoplasmic reticulum , unfolded protein response , photothermal therapy , in vivo , reactive oxygen species , intracellular , biophysics , in vitro , flow cytometry , cancer cell , cancer research , chemistry , materials science , microbiology and biotechnology , cancer , biochemistry , nanotechnology , medicine , biology
Recently, nanocatalyst-induced endoplasmic reticulum (ER) stress for cancer therapy has been attracting considerable attention. However, cancer cells are often able to overcome ER stress-induced death by activating the unfolded protein response (UPR), making nanocatalytic monotherapy a poor defense against cancer progression.