Open AccessNanohydroxyapatite, Nanosilicate-Reinforced Injectable, and Biomimetic Gelatin-Methacryloyl Hydrogel for Bone Tissue Engineering
Author(s) -
Zhe Shi,
Qiang Zhong,
Yuhang Chen,
Jian Gao,
Xuran Pan,
Qi Lian,
Rong Chen,
Pinkai Wang,
Jian Wang,
Hao Cheng
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s321387
Subject(s) - gelatin , self healing hydrogels , biomedical engineering , extracellular matrix , mesenchymal stem cell , tissue engineering , materials science , calvaria , in vivo , regeneration (biology) , bone tissue , chemistry , in vitro , microbiology and biotechnology , medicine , polymer chemistry , biochemistry , biology
Given that autologous bone graft for bone defects is limited by insufficient supply and morbidity at the donor site, developing biomimetic graft materials as an alternative has gained consistent attention. However, obstacles in designing bone-mimetic materials that could integrate the biomimetic nature of the bone extracellular matrix, osteogenic cells, and osteoinductive ingredients with a fast and convenient strategy still exist.