Open AccessImplementing Spanlastics for Improving the Ocular Delivery of Clotrimazole: In vitro Characterization, Ex vivo Permeability, Microbiological Assessment and In vivo Safety Study
Author(s) -
Manar Adel Abdelbari,
Shereen S. El-Mancy,
Ahmed Hassen Elshafeey,
Ahmed Abdelbary
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s319348
Subject(s) - ex vivo , permeation , in vivo , zeta potential , clotrimazole , factorial experiment , dispersity , drug delivery , chemistry , chromatography , materials science , membrane , in vitro , nanotechnology , nanoparticle , antifungal , biochemistry , biology , mathematics , microbiology and biotechnology , statistics , organic chemistry
The aim of this study was to encapsulate clotrimazole (CLT), an antifungal drug with poor water solubility characteristics, into spanlastics (SPs) to provide a controlled ocular delivery of the drug.