Open AccessRGD Peptide and PAD4 Inhibitor-Loaded Gold Nanorods for Chemo-Photothermal Combined Therapy to Inhibit Tumor Growth, Prevent Lung Metastasis and Improve Biosafety
Author(s) -
Yu Lu,
Zidong Peng,
Di Zhu,
Yijiang Jia,
Ayijiang Taledaohan,
Yuanming Li,
Jiawang Liu,
Yanming Wang,
Yuji Wang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s319210
Subject(s) - photothermal therapy , in vivo , cancer research , nanorod , materials science , pharmacology , medicine , chemistry , nanotechnology , biology , microbiology and biotechnology
A targeted drug delivery system that combines protein-arginine deiminase type-4 (PAD4) inhibitors YW3-56 (356) with PTT of NPs is constructed to both decrease the accumulation of gold in metabolic organs and reduce the dose of chemotherapeutic agents.