Open AccessDesign and Optimization of New Enteric Nanoparticles of Ceftriaxone for Oral Delivery: In vitro and in vivo Assessments
Author(s) -
Amir E Maghrabia,
Mariza Fouad Boughdady,
Mahasen Mohamed Meshali
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s319176
Subject(s) - in vivo , ceftriaxone , in vitro , nanoparticle , materials science , pharmacology , nanotechnology , medicine , microbiology and biotechnology , antibiotics , chemistry , biology , biochemistry
Development of new strategies for oral delivery of existing antibiotics administered exclusively through intravenous route is one of the global priorities of pharmaceutical research. The encapsulation of these active pharmaceutical agents within nanosized natural products offers several traits due to their tunable surface properties. Ceftriaxone (CTX) is an injectable, third-generation cephalosporin that suffers poor oral bioavailability.