Open AccessAn Acceptor-π-Donor Structured Organic Chromophore for NIR Triggered Thermal Ablation of Tumor via DNA Damage-Mediated Apoptosis
Author(s) -
Di Zhang,
Jinghong Yang,
Chuang Liu,
Sheng Ye,
Qianbing Zhang,
Ruiyuan Liu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s319089
Subject(s) - photothermal therapy , chromophore , materials science , biophysics , apoptosis , in vivo , tumor ablation , dna damage , ablation , photochemistry , nanotechnology , dna , chemistry , biochemistry , biology , microbiology and biotechnology , aerospace engineering , engineering
It will be challenging to develop high-performance organic chromophores for light-triggered thermal ablation of the tumor. Besides, the mechanisms of organic chromophores for tumor therapy remain unclear. Herein, an acceptor-π-donor (A-π-D) structured organic chromophore based on 2-dicyanomethylenethiazole named PTM was developed for photothermal therapy (PTT) of tumors.