Open AccessIndocyanine Green-Based Theranostic Nanoplatform for NIR Fluorescence Image-Guided Chemo/Photothermal Therapy of Cervical Cancer
Author(s) -
Rong Ma,
Nuernisha Alifu,
Zhimin Du,
Shuang Chen,
Youqiang Heng,
Jing Wang,
Lijun Zhu,
Cailing Ma,
Xueliang Zhang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s318678
Subject(s) - indocyanine green , biocompatibility , photothermal therapy , doxorubicin , fluorescence lifetime imaging microscopy , bovine serum albumin , fluorescence , nanoprobe , drug delivery , photothermal effect , chemistry , materials science , biomedical engineering , nanoparticle , nanotechnology , medicine , chemotherapy , pathology , chromatography , surgery , organic chemistry , physics , quantum mechanics
Indocyanine green (ICG) is a favorable fluorescence nanoprobe for its strong NIR-I fluorescence emission and good photothermal capabilities. However, the stability and tumor targeting ability of ICG is poor, which limits its further applications. To further improve the photothermal and therapeutic efficiency of ICG, bovine serum albumin (BSA) was utilized to encapsulate the ICG and the chemotherapeutic drug doxorubicin (DOX) was loaded to form the BSA@ICG-DOX theranostic nanoplatform.