Open AccessChromium Oxide Nanoparticle Impaired Osteogenesis and Cellular Response to Mechanical Stimulus
Author(s) -
Jian Chen,
Jing Ding,
Yuanhao Wu,
Shuqiong Zhang,
Naisheng Zheng,
Junyao Yang,
Jing Xu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s317430
Subject(s) - mesenchymal stem cell , in vivo , biophysics , materials science , stimulation , flow cytometry , microbiology and biotechnology , chemistry , biomedical engineering , immunology , medicine , biology
Release of metallic wear particles from hip replacement implants is closely associated with aseptic loosening that affects the functionality and survivorship of the prostheses. Chromium oxide nanoparticles (CrNPs) are the dominant form of the wear particles found in the periprosthetic tissues. Whether CrNPs play a role in the clinically observed particle-induced osteolysis, tissue inflammatory reactions and functional activities of human mesenchymal stem cells (MSCs) remain unknown.