Open AccessStructural Deformation of MTX Induced by Nanodrug Conjugation Dictate Intracellular Drug Transport and Drug Efficacy
Author(s) -
Jun-Young Park,
Ja-Shil Hyun,
Jun-Goo Jee,
Sung Jean Park,
Dongwoo Khang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s317231
Subject(s) - covalent bond , drug , conjugated system , biophysics , pegylation , drug delivery , intracellular , materials science , chemistry , nanotechnology , pharmacology , biochemistry , organic chemistry , polymer , medicine , polyethylene glycol , biology
Understanding structural interactions between the active drug and conjugated nanoparticles is critical for optimizing intracellular drug transport and for increasing nano drug efficacy. In this regard, analyzing the conformational deformation of conjugated drugs surrounding nanoparticles is essential to understand the corresponding nanodrug efficacy.