Open AccessNanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models
Author(s) -
Qiqi Feng,
Mengyang Wang,
Eldar Muhtar,
Yaonan Wang,
Haimei Zhu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s316863
Subject(s) - in vivo , pharmacology , inflammation , chemistry , in vitro , thrombosis , platelet , medicine , biochemistry , immunology , biology , microbiology and biotechnology
To assess whether the newly designed small-molecule oral P-selectin inhibitor 3 S -1,2,3,4-tetrahydro-β-carboline-3-methyl aspartyl ester (THCMA) as a nanomedicine enhances antithrombosis, anti-inflammation, and antitumor activity more than the clinical trial drug PSI-697.