Open AccessTherapeutic Effect of IL-4 Receptor-Targeting Pro-Apoptotic Peptide (AP1-ELP-KLAK) in Glioblastoma Tumor Model
Author(s) -
Vijaya Sarangthem,
Aena Yi,
Yun-Jae Kim,
Alnawaz Rehemtulla,
Byungheon Lee,
Young Jin Jeon,
Thoudam Debraj Singh,
Rang-Woon Park
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s316388
Subject(s) - ap 1 transcription factor , apoptosis , cancer research , ex vivo , biodistribution , in vivo , microbiology and biotechnology , biology , biochemistry , gene expression , gene
Thermal-responsive self-assembled elastin-like polypeptide (ELP)-based nanoparticles are an emerging platform for controlled delivery of therapeutic peptides, proteins and small molecular drugs. The antitumor effect of bioengineered chimeric polypeptide AP1-ELP-KLAK containing an interleukin-4 receptor (IL-4R) targeting peptide and pro-apoptotic peptide (KLAKLAK) was evaluated in glioblastoma (GBM) in vitro and in vivo .