Open AccessRobust Immune Response Induced by Schistosoma mansoni TSP-2 Antigen Coupled to Bacterial Outer Membrane Vesicles
Author(s) -
Mayra Mara Ferrari Barbosa,
Alex I. Kanno,
Giovana Cappio Barazzone,
Dunia Rodríguez,
Violeta Pancakova,
Monalisa Martins Trentini,
Eliana L. Faquim-Mauro,
Amanda Pereira de Freitas,
Mariana I. Khouri,
Jéssica Lobo-Silva,
Viviane Maimoni Gonçalves,
Rocilda P.F. Schenkman,
Martha M. Tanizaki,
Diana Boraschi,
Richard Malley,
Leonardo P. Farias,
Luciana C. C. Leite
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s315786
Subject(s) - immunogenicity , bacterial outer membrane , immune system , antigen , biotinylation , adjuvant , biology , microbiology and biotechnology , schistosoma mansoni , chemistry , immunology , biochemistry , escherichia coli , schistosomiasis , gene , helminths
The use of adjuvants can significantly strengthen a vaccine's efficacy. We sought to explore the immunization efficacy of bacterial outer membrane vesicles (OMVs) displaying the Schistosoma mansoni antigen, SmTSP-2, through a biotin-rhizavidin coupling approach. The rationale is to exploit the nanoparticulate structure and the adjuvant properties of OMVs to induce a robust antigen-specific immune response, in light of developing new vaccines against S. mansoni.