Open AccessOptimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles
Author(s) -
Hee Ji Shin,
Min Jeong Jo,
Ik Sup Jin,
ChunWoong Park,
Jinseok Kim,
Dae Hwan Shin
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s315782
Subject(s) - micelle , in vivo , biodistribution , pharmacokinetics , ethylene glycol , nanocarriers , chemistry , materials science , nuclear chemistry , pharmacology , drug delivery , in vitro , biochemistry , organic chemistry , medicine , aqueous solution , biology , microbiology and biotechnology
We aimed to develop a nanocarrier formulation incorporating fenbendazole (FEN) and rapamycin (RAPA) with strong efficacy against A549 cancer cells. As FEN and RAPA are poorly soluble in water, it is difficult to apply them clinically in vivo. Therefore, we attempted to resolve this problem by encapsulating these drugs in polymeric micelles.