Open AccessAu Nanoclusters Ameliorate Shigella Infectious Colitis by Inducing Oxidative Stress
Author(s) -
Xiaoxiao Wu,
Yongyan Chen,
Yangheng Zhang,
Yunjie Shan,
Zhiyue Peng,
Bing Gu,
Huan Yang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s315481
Subject(s) - shigella , shigella flexneri , microbiology and biotechnology , antibiotics , oxidative stress , chemistry , reactive oxygen species , bacteria , biology , salmonella , biochemistry , escherichia coli , genetics , gene
Shigella infection has always been a global burden, and it particularly threatens children between the ages of 1 and 5 years. Economically underdeveloped countries are dominated by Shigella flexneri infection. The most effective method to treat Shigella is antibiotics, but with the abuse of antibiotics and the prevalence of multidrug resistance, we urgently need a relatively safe non-antibiotic treatment to replace it. Ultrasmall Au nanoclusters (NCs) have special physical and chemical properties and can better interact with and be internalized by bacteria to disrupt the metabolic balance. The purpose of this study was to explore whether Au NCs may be a substitute for antibiotics to treat Shigella infections.