Open AccessInjectable Nanosponge-Loaded Pluronic F127 Hydrogel for Pore-Forming Toxin Neutralization
Author(s) -
Shuaijun Zou,
Qian He,
Qianqian Wang,
Bo Wang,
Guoyan Liu,
Fuhai Zhang,
Xi Cheng,
Beilei Wang,
Liming Zhang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s315062
Subject(s) - biocompatibility , poloxamer , self healing hydrogels , in vivo , hemolysis , materials science , biodegradation , chemistry , polymer , copolymer , polymer chemistry , organic chemistry , composite material , microbiology and biotechnology , immunology , metallurgy , biology
Pore-forming toxins (PFTs) perform important functions during bacterial infections. Among various virulence-targeting therapies, nanosponges (NSs) have excellent neutralization effects on multiple PFTs. To enhance treatment efficacy, NSs tend to be incorporated into other biomaterials, such as hydrogels.