Open AccessDoxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice
Author(s) -
Jia Ouyang,
Yu Jiang,
Chao Deng,
Zhiyuan Zhong,
Qing Lan
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s314895
Subject(s) - doxorubicin , polymersome , pharmacology , apolipoprotein e , nude mouse , flow cytometry , apoptosis , medicine , cancer research , ic50 , chemotherapy , chemistry , pathology , in vitro , immunology , biochemistry , disease , organic chemistry , copolymer , amphiphile , polymer
Glioblastoma multiforme (GBM) poorly responds to chemotherapy owing to the existence of blood-brain barriers (BBB). It has been a long desire to develop BBB-permeable vehicles to facilitate drug targeting to GBM.