Open AccessDoxorubicin-Bound Hydroxyethyl Starch Conjugate Nanoparticles with pH/Redox Responsive Linkage for Enhancing Antitumor Therapy
Author(s) -
Ronghua Tan,
Danlei Tian,
Jiaoyan Liu,
Congcong Wang,
Ying Wan
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s314705
Subject(s) - conjugate , doxorubicin , intracellular , hydroxyethyl starch , disulfide linkage , pharmacology , chemistry , redox , biophysics , drug delivery , biochemistry , chemotherapy , medicine , biology , organic chemistry , enzyme , mathematical analysis , mathematics , cysteine
Chemotherapeutic drugs used for tumor treatments often show limited efficiency due to their short lifetime, nonspecific delivery, and slow or insufficient intracellular drug release, and also, they can cause severe system or organ toxicity. The development of chemotherapeutic nanomedicines with high efficacy and satisfactory safety still remains a challenge for current tumor chemotherapy.