Open AccessTumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
Author(s) -
Qi Li,
Suna Cai,
Mengjiao Li,
Kab Ibrahim Salma,
Xiaojie Zhou,
Feiyu Han,
Chen Jin-zhao,
Ting Huyan
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s313912
Subject(s) - immune system , extracellular , immunotherapy , extracellular vesicles , extracellular vesicle , biology , microbiology and biotechnology , intracellular , microvesicles , cancer research , immunology , biochemistry , microrna , gene
Nowadays, tumor has been the serious threat to human health and life. To further explore the mechanism of tumor genesis and development is necessarily for developing the effective treatment strategy. Extracellular vesicles are the vesicles secreted by almost all types of cells, and they play an important part in intercellular communication by transporting their cargoes. Immune cells are the vital components of the human defense system, which defense against infection and tumor through cytotoxicity, immune surveillance, and clearance. However, via release tumor-derived extracellular vesicles, tumor could induce immune cells dysfunction to facilitate its proliferation and metastasis. Studies have shown that tumor-derived extracellular vesicles play dual role on immune cells by their specific cargoes. Here, we reviewed the effects of tumor-derived extracellular vesicles on immune cells in recent years and also summarized their research progress in the tumor immunotherapy and diagnosis.