Open AccessNovel Timosaponin AIII-Based Multifunctional Liposomal Delivery System for Synergistic Therapy Against Hepatocellular Carcinoma Cancer
Author(s) -
Lijuan Zhang,
Shengan Zhang,
Min Jiang,
Lu Lu,
Yue Ding,
Ninghui Ma,
Yuan Zhao,
Sihan Xuchen,
Nailian Zhang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s313759
Subject(s) - liposome , doxorubicin , pharmacology , cardiotoxicity , hepatocellular carcinoma , cytotoxicity , transplantation , chemistry , doxorubicin hydrochloride , drug delivery , cholesterol , medicine , cancer research , in vitro , toxicity , chemotherapy , biochemistry , organic chemistry
As high cholesterol level has been reported to be associated with cancer cell growth and cholesterol is vulnerable to oxidation, the conventional liposomes including cholesterol in the formulation seem to be challenged. Timosaponin AIII (TAIII), as a steroid saponin from Anemarrhena asphodeloides Bunge, possesses a similar structure with cholesterol and exhibits a wide range of antitumor activities, making it possible to develop a TAIII-based liposome where TAIII could potentially stabilize the phospholipid bilayer as a substitution of cholesterol and work as a chemotherapeutic drug as well. Meanwhile, TAIII could enhance the uptake of doxorubicin hydrochloride (DOX) in human hepatocellular carcinoma (HCC) cells and exhibit synergistic effect. Thus, we designed a novel thermally sensitive multifunctional liposomal system composed of TAIII and lipids to deliver DOX for enhanced HCC treatment.