Open AccessTherapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study
Author(s) -
Pengcheng Zhang,
Bang-Ying Yu,
Xiaodong Jin,
Ting Zhao,
Fei Ye,
Xiongxiong Liu,
Ping Li,
Xiaogang Zheng,
Weiqiang Chen,
Qiang Li
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s313678
Subject(s) - in vivo , apoptosis , colloidal gold , in vitro , intracellular , reactive oxygen species , biophysics , radiosensitivity , materials science , irradiation , chemistry , cancer research , biochemistry , nanoparticle , nanotechnology , biology , physics , microbiology and biotechnology , nuclear physics
Gold nanoparticles (AuNPs) are widely studied as radiosensitizers, but their radiosensitization in carbon ion radiotherapy is unsatisfactory. There is a lack of in vivo data on the radiosensitization of AuNPs under carbon ion irradiation. This study focused on the radiosensitization effect of AuNPs in the mouse melanoma cell line B16-F10 in vitro and in vivo.