Open AccessSurfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity
Author(s) -
Lina Gao,
Lei Zhang,
Feng-Jun He,
Jing Chen,
Meng Zhao,
Simin Li,
Hao Wu,
Yumeng Liu,
Yinan Zhang,
Qineng Ping,
Lihong Hu,
Hongzhi Qiao
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s313153
Subject(s) - cardiotoxicity , in vivo , biodistribution , pharmacology , liposome , poloxamer , pharmacokinetics , bioavailability , chemistry , therapeutic index , toxicity , bufalin , in vitro , drug , medicine , biochemistry , apoptosis , microbiology and biotechnology , organic chemistry , copolymer , biology , polymer
BF211, a derivative of bufalin (BF), shows significantly improved solubility and potent antitumor efficiency compared to BF. Unfortunately, the unwanted toxicity such as cardiotoxicity caused by unspecific distribution has hindered its clinical use.