Open AccessEffective Oxidation-Responsive Polyester Nanocarriers for Anti-Inflammatory Drug Delivery
Author(s) -
Pan He,
Bingtong Tang,
Yusheng Li,
Yu Zhang,
Xinming Liu,
Xin Guo,
Dong Wang,
Peng She,
Chunsheng Xiao
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s311718
Subject(s) - nanocarriers , ethylene glycol , reactive oxygen species , drug delivery , pharmacology , chemistry , cytotoxicity , proinflammatory cytokine , inflammation , materials science , in vitro , biochemistry , organic chemistry , medicine , immunology
High levels of oxidants, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are typical characteristics of an inflammatory microenvironment and are closely associated with a various inflammatory pathologies, eg, cancer, diabetes, atherosclerosis, and neurodegenerative diseases. Therefore, the delivery of anti-inflammatory drugs by oxidation-responsive smart systems would be an efficient anti-inflammatory strategy that benefits from the selective drug release in an inflammatory site, a lower treatment dose, and minimizes side effects.