Open AccessEmerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment
Author(s) -
Wenli Zhang,
Enshi Hu,
Yajie Wang,
Si Miao,
Yanyan Liu,
Yumin Hu,
Liu Ji,
Bohui Xu,
Daquan Chen,
Yan Shen
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s311248
Subject(s) - nanocarriers , drug delivery , antimicrobial , antibiotics , targeted drug delivery , drug , drug resistance , antibiotic resistance , nanotechnology , medicine , pharmacology , microbiology and biotechnology , biology , materials science
At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiotic delivery system to improve drug delivery behavior, in order to delay the generation of bacterial drug resistance. In recent years, with the continuous development of nanotechnology, various types of nanocarriers that respond to the infection microenvironment, targeting specific bacterial targets, and targeting infected cells, and so on, are gradually being used in the delivery of antibacterial agents to increase the concentration of drugs at the site of infection and reduce the side effects of drugs in normal tissues. Here, this article describes in detail the latest research progress on nanocarriers for antimicrobial, and commonly used targeted antimicrobial strategies. The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected.