Open AccessA Novel Silicon Platform for Selective Isolation, Quantification, and Molecular Analysis of Small Extracellular Vesicles
Author(s) -
Antonio Alessio Leonardi,
Rosalia Battaglia,
Dario Morganti,
Barbara Fazio,
Chiara De Pascali,
Luca Francioso,
Gerardo Palazzo,
Antonia Mallardi,
Michele Purrello,
F. Priolo,
Paolo Musumeci,
Cinzia Di Pietro,
Alessia Irrera
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s310896
Subject(s) - nanotechnology , detection limit , extracellular vesicles , materials science , computer science , computational biology , biology , microbiology and biotechnology , chemistry , chromatography
Small extracellular vesicles (sEVs), thanks to their cargo, are involved in cellular communication and play important roles in cell proliferation, growth, differentiation, apoptosis, stemness and embryo development. Their contribution to human pathology has been widely demonstrated and they are emerging as strategic biomarkers of cancer, neurodegenerative and cardiovascular diseases, and as potential targets for therapeutic intervention. However, the use of sEVs for medical applications is still limited due to the selectivity and sensitivity limits of the commonly applied approaches.