Open AccessEfficient Determination of PML/RARα Fusion Gene by the Electrochemical DNA Biosensor Based on Carbon Dots/Graphene Oxide Nanocomposites
Author(s) -
Ziyang Zhang,
Lin-Xiao Huang,
Zhiwei Xu,
Peng Wang,
Yun Lei,
Ailin Liu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s308258
Subject(s) - graphene , biosensor , nanocomposite , materials science , oxide , nanotechnology , biocompatibility , dna , electrochemistry , detection limit , electrode , carbon fibers , chemistry , biochemistry , composite number , chromatography , metallurgy , composite material
The PML/RARα fusion gene as a leukemogenesis plays a significant role in clinical diagnosis of the early stage of acute promyelocytic leukemia (APL). Here, we present an electrochemical biosensor for PML/RARα fusion gene detection using carbon dots functionalized graphene oxide (CDs/GO) nanocomposites modified glassy carbon electrode (CDs/GO/GCE).