Open AccessIntratumoral Administration of Thermosensitive Hydrogel Co-Loaded with Norcantharidin Nanoparticles and Doxorubicin for the Treatment of Hepatocellular Carcinoma
Author(s) -
Benjian Gao,
Jia Luo,
Ying Li,
Song Su,
Fu Shao,
Xiaoli Yang,
Bo Li
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s308057
Subject(s) - doxorubicin , in vivo , pharmacology , hepatocellular carcinoma , drug delivery , drug , chemistry , materials science , cancer research , medicine , chemotherapy , nanotechnology , surgery , microbiology and biotechnology , biology
The efficacy of systemic chemotherapy for hepatocellular carcinoma (HCC) is predominantly hampered by low accumulation in tumor tissue and the high systemic toxicity of anticancer drugs. In this study, we designed an in situ drug-loaded injectable thermosensitive hydrogel system for the simultaneous delivery of norcantharidin-loaded nanoparticles (NCTD-NPs) and doxorubicin (Dox) via intratumoral administration to HCC tumors.