Open AccessHigh-Specific Isolation and Instant Observation of Circulating Tumour Cell from HCC Patients via Glypican-3 Immunomagnetic Fluorescent Nanodevice
Author(s) -
Qihui Chu,
Weiwei Mu,
Chuanjin Lan,
Yang Liu,
Tong Gao,
Li Guan,
Yongjun Fang,
Zipeng Zhang,
Yingchao Liu,
Yongjun Liu,
Na Zhang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s307691
Subject(s) - glypican 3 , nanodevice , fluorescence , isolation (microbiology) , cancer research , materials science , hepatocellular carcinoma , nanotechnology , medicine , biology , bioinformatics , physics , quantum mechanics
Specific targeting receptors for efficiently capturing and applicable nanodevice for separating and instant observing of circulating tumour cells (CTC) are critical for early diagnosis of cancer. However, the existing CTC detection system based on epithelial cell adhesion molecule (EpCAM) was seriously limited by low expression and poor specificity of targeting receptors, and not instant observation in clinical application.