Open AccessEnhancement of T2* Weighted MRI Imaging Sensitivity of U87MG Glioblastoma Cells Using γ-Ray Irradiated Low Molecular Weight Hyaluronic Acid-Conjugated Iron Nanoparticles
Author(s) -
Haw Ming Huang,
Ping Wu,
Po Chien Chou,
Wen Tien Hsiao,
Hsin-Ta Wang,
Hsin Pei Chiang,
Chi-Ming Lee,
Shwu Huey Wang,
Yu Cheng Hsiao
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s307648
Subject(s) - biocompatibility , viability assay , materials science , hyaluronic acid , nanoprobe , nanoparticle , biophysics , chemistry , cell , nanotechnology , medicine , biochemistry , anatomy , biology , metallurgy
It has been reported that low-molecular-weight hyaluronic acid (LMWHA) exhibits a potentially beneficial effect on cancer therapy through targeting of CD44 receptors on tumor cell surfaces. However, its applicability towards tumor detection is still unclear. In this regard, LMWHA-conjugated iron (Fe 3 O 4 ) nanoparticles (LMWHA-IONPs) were prepared in order to evaluate its application for enhancing the T2* weighted MRI imaging sensitivity for tumor detection.