Open AccessSize-Dependent Cytotoxicity and Reactive Oxygen Species of Cerium Oxide Nanoparticles in Human Retinal Pigment Epithelia Cells
Author(s) -
Yuanyuan Ma,
Peng Li,
Laien Zhao,
Jia Liu,
Yu Jin,
Yanmei Huang,
Yuting Zhu,
Zelin Li,
Ruikang Zhao,
Hua Shi,
Yanping Zhu,
Zhuhong Zhang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s305676
Subject(s) - cytotoxicity , reactive oxygen species , biophysics , cerium oxide , nanotoxicology , chemistry , microbiology and biotechnology , in vitro , materials science , biochemistry , nanoparticle , biology , nanotechnology , catalysis
The use of cerium oxide nanoparticles (CeO 2 NPs), a lanthanide element oxide and bivalent compound, has been growing continuously in industry and biomedicine. Due to their wide application, the potential human health problems of CeO 2 NPs have attracted attention, but studies on the toxicity of this compound to human eyes are lacking. This study investigated the cytotoxicity and reactive oxygen species (ROS) of CeO 2 NPs in human retinal pigment epithelial cells (ARPE-19 cells).