Open AccessStudy of Uptake Mechanisms of Halloysite Nanotubes in Different Cell Lines
Author(s) -
Giuseppa Biddeci,
Gaetano Spinelli,
Marina Massaro,
Serena Riela,
Paola Bonaccorsi,
Anna Barattucci,
Francesco Blasi
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s303816
Subject(s) - endocytosis , internalization , halloysite , microbiology and biotechnology , biophysics , phagocytosis , nanotoxicology , cell culture , chemistry , materials science , nanotechnology , cell , nanoparticle , biochemistry , biology , genetics , composite material
Halloysite nanotubes (HNTs) are a natural aluminosilicate clay with a chemical formula of Al 2 Si 2 O 5 (OH) 4 ×nH 2 O and a hollow tubular structure. Due to their peculiar structure, HNTs can play an important role as a drug carrier system. Currently, the mechanism by which HNTs are internalized into living cells, and what is the transport pathway, is still unclear. Therefore, this study aimed at establishing the in vitro mechanism by which halloysite nanotubes could be internalized, using phagocytic and non-phagocytic cell lines as models.