Open AccessNano-Sized Hydroxyapatite Induces Apoptosis and Osteogenic Differentiation of Vascular Smooth Muscle Cells via JNK/c-JUN Pathway
Author(s) -
Qi Liu,
Pingping Xiang,
Mingyao Chen,
Yi Luo,
Yun Zhao,
Junfeng Zhu,
Wangwei Jing,
Hong Yu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s303714
Subject(s) - apoptosis , vascular smooth muscle , microbiology and biotechnology , materials science , smooth muscle , biophysics , chemistry , biochemistry , biology , medicine
The deposition of hydroxyapatite (HAp) crystals plays an important role in the development of vascular calcification (VC). This study aimed to demonstrate the effects of nanosized HAp (nHAp) on vascular smooth muscle cells (VSMCs) and VC progression.