Open AccessNanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast – A Novel Concept for Osteoporosis Treatment: Part 1
Author(s) -
Krzysztof Marycz,
Agnieszka Śmieszek,
Klaudia Marcinkowska,
Mateusz Sikora,
Eliza Turlej,
Paulina Sobierajska,
Adrian Patej,
Alina Bieńko,
Rafał J. Wiglusz
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s303412
Subject(s) - viability assay , osteoblast , bone remodeling , osteoclast , biomaterial , chemistry , materials science , biophysics , microbiology and biotechnology , biomedical engineering , biochemistry , nanotechnology , in vitro , medicine , biology
Osteoporosis results in a severe decrease in the life quality of many people worldwide. The latest data shows that the number of osteoporotic fractures is becoming an increasing international health service problem. Therefore, a new kind of controllable treatment methods for osteoporotic fractures is extensively desired. For that reason, we have manufactured and evaluated nanohydroxyapatite (nHAp)-based composite co-doped with iron oxide (IO) nanoparticles. The biomaterial was used as a matrix for the controlled delivery of miR-21-5p and miR-124-3p, which have a proven impact on bone cell metabolism.