Open AccessFabrication of Submicro-Nano Structures on Polyetheretherketone Surface by Femtosecond Laser for Exciting Cellular Responses of MC3T3-E1 Cells/Gingival Epithelial Cells
Author(s) -
Dong Xie,
Chenhui Xu,
Ya Cheng,
Shiqi Mei,
Longqing Wang,
Qi Zhu,
Qing Chen,
Qi Zhao,
Zhiyan Xu,
Lili Yang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s303411
Subject(s) - peek , materials science , biocompatibility , adhesion , alkaline phosphatase , surface roughness , surface energy , cell adhesion , osseointegration , nanotechnology , in vitro , biophysics , biomedical engineering , implant , chemistry , composite material , medicine , biology , biochemistry , surgery , metallurgy , enzyme , polymer
Polyetheretherketone (PEEK) exhibits high mechanical strengths and outstanding biocompatibility but biological inertness that does not excite the cell responses and stimulate bone formation. The objective of this study was to construct submicro-nano structures on PEEK by femtosecond laser (FSL) for exciting the responses of MC3T3-E1 cells and gingival epithelial (GE) cells, which induce regeneration of bone/gingival tissues for long-term stability of dental implants.