Open AccessDevelopment and Evaluation of Curcumin Encapsulated Self-assembled Nanoparticles as Potential Remedial Treatment for PCOS in a Female Rat Model
Author(s) -
Mazhar Ali Raja,
Martín Maldonado,
Jianying Chen,
Ying Zhong,
Jiang Gu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s302161
Subject(s) - curcumin , zeta potential , chitosan , nanoparticle , sonication , pharmacology , conjugate , arginine , drug delivery , chemistry , drug carrier , cytotoxicity , in vitro , nuclear chemistry , drug , materials science , medicine , biochemistry , nanotechnology , chromatography , organic chemistry , amino acid , mathematical analysis , mathematics
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women of reproductive age and leads to metabolic disorders and infertility. The present study was conducted to investigate the therapeutic effects of curcumin (Cur) encapsulated arginine (Arg) and N-acetyl histidine (NAcHis) modified chitosan (Arg-CS-NAcHis/Cur) nanoparticles (NPs).