Open AccessA Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
Author(s) -
Hairong Wang,
Yawen Zhang,
Xiangle Zeng,
Wenjie Pei,
Rong Fan,
Yushuai Wang,
Xiu Wang,
Jianchun Li
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s299681
Subject(s) - in vivo , metastasis , nanomedicine , cancer research , dasatinib , drug delivery , pharmacology , cancer , cytotoxicity , breast cancer , paclitaxel , doxorubicin , cancer cell , in vitro , drug , medicine , chemistry , materials science , chemotherapy , nanotechnology , nanoparticle , imatinib , biology , biochemistry , microbiology and biotechnology , myeloid leukemia
The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell metastasis. Due to the poor water solubility, short half-time in the body of DAS and ROZ, which increases the difficulty of tumor treatment, as well as the demand for nano-drug delivery systems for organ-specific therapies.