Open AccessAntibiotic-Loaded MMT/PLL-Based Coating on the Surface of Endosseous Implants to Suppress Bacterial Infections
Author(s) -
Xingfang Yu,
Xin Liao,
Hongwei Chen
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s299154
Subject(s) - materials science , coating , montmorillonite , scanning electron microscope , antibiotics , biomedical engineering , implant , layer (electronics) , composite material , microbiology and biotechnology , medicine , surgery , biology
Bone infections remain one of the most common and serious complications of orthopedic surgery, posing a tremendous economic burden to society and patients. This is because bacteria colonize and multiply on the surface of the implant. The (MMT/PLL) 8 multilayer films have been shown to effectively release antibiotics depending on the changes in the microenvironment. Here, vancomycin was loaded into the (MMT/PLL) 8 multilayer films, which were prepared to be used as a local delivery system for the treatment of bone infections.