Open AccessAntitumor Effect of Hyperoside Loaded in Charge Reversed and Mitochondria-Targeted Liposomes
Author(s) -
Yukuan Feng,
Guozhao Qin,
Shuyuan Chang,
Zhongxu Jing,
Yanyan Zhang,
Yanhong Wang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s297716
Subject(s) - liposome , mitochondrion , chemistry , in vivo , apoptosis , drug delivery , in vitro , zeta potential , biophysics , hyperoside , biochemistry , internalization , pharmacology , cancer cell , biology , materials science , antioxidant , cancer , cell , nanotechnology , nanoparticle , genetics , microbiology and biotechnology , organic chemistry , rutin
Hyperoside (HYP), a flavonol glycoside compound, has been shown to significantly inhibit the proliferation of malignant tumors. Mitochondria serve as both "energy factories" and "suicide weapon stores" of cells. Targeted delivery of cytotoxic drugs to the mitochondria of tumor cells and tumor vascular cells is a promising strategy to improve the efficacy of chemotherapy.