Open AccessTherapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDR Acinetobacter baumannii: In silico, in vitro and in vivo Studies
Author(s) -
Ali Hassan,
Aamer Ikram,
Abida Raza,
Soobia Saeed,
Rehan Zafar Paracha,
Zumara Younas,
Muhammad Tahir Khadim
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s296717
Subject(s) - mastoparan , acinetobacter baumannii , chitosan , in vivo , chemistry , materials science , biochemistry , biology , pseudomonas aeruginosa , bacteria , receptor , microbiology and biotechnology , g protein , genetics
Acinetobacter baumannii antibiotic resistant infections in high-risk patients are a great challenge for researchers and clinicians worldwide. In an effort to achieve potent bactericidal outcomes, a novel chitosan-mastoparan nanoconstruct (Mast-Cs NC) was designed and assessed for its therapeutic potential through in silico, in vitro and in vivo experimentation against clinical multidrug-resistant (MDR) A. baumannii .