Open AccessA Multiepitope Peptide, rOmp22, Encapsulated in Chitosan-PLGA Nanoparticles as a Candidate Vaccine Against Acinetobacter baumannii Infection
Author(s) -
Xingran Du,
Jianpeng Xue,
Mingkun Jiang,
Shunquan Lin,
Yuzhen Huang,
Kaili Deng,
Lei Shu,
Huan Xu,
Zeqing Li,
Jing Yao,
Sixia Chen,
Ziyan Shen,
Ganzhu Feng
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s296527
Subject(s) - immunogenicity , acinetobacter baumannii , plga , microbiology and biotechnology , adjuvant , immune system , antibody , epitope , chemistry , biology , immunology , in vitro , biochemistry , bacteria , pseudomonas aeruginosa , genetics
The development of vaccines is a promising and cost-effective strategy to prevent emerging multidrug-resistant (MDR) Acinetobacter baumannii ( A. baumannii ) infections. The purpose of this study was to prepare a multiepitope peptide nanovaccine and evaluate its immunogenicity and protective effect in BALB/c mice.