Open AccessCombined Photothermal and Ionizing Radiation Sensitization of Triple-Negative Breast Cancer Using Triangular Silver Nanoparticles
Author(s) -
James J. Sears,
Jessica Swanner,
Cale D. Fahrenholtz,
Christina Snyder,
Monica Rohde,
Nicole LeviPolyachenko,
Ravi Singh
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s296513
Subject(s) - triple negative breast cancer , photothermal therapy , hyperthermia , sensitization , ionizing radiation , breast cancer , cancer research , radiation therapy , irradiation , non ionizing radiation , cancer , hyperthermia treatment , medicine , materials science , nanotechnology , immunology , physics , quantum mechanics , nuclear physics
Ionizing radiation (IR) is commonly used in triple-negative breast cancer (TNBC) treatment regimens. However, off-target toxicity affecting normal tissue and grueling treatment regimens remain major limitations. Hyperthermia is one of the greatest IR sensitizers, but only if heat is administered simultaneously or immediately prior to ionizing radiation. Difficulty in co-localizing ionizing radiation (IR) in rapid succession with hyperthermia, and confining treatment to the tumor have hindered widespread clinical adoption of combined thermoradiation treatment. Metal nanoparticle-based approaches to IR sensitization and photothermal heat generation may aid in overcoming these issues and improve treatment specificity.