Open AccessFe3O4@Polydopamine-Labeled MSCs Targeting the Spinal Cord to Treat Neuropathic Pain Under the Guidance of a Magnetic Field
Author(s) -
Meichen Liu,
Weijia Yu,
Fuqiang Zhang,
Te Liu,
Kai Li,
Meng Lin,
Ying Wang,
Guoqing Zhao,
Jinlan Jiang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s296398
Subject(s) - mesenchymal stem cell , neuropathic pain , spinal cord , medicine , astrocyte , homing (biology) , microglia , flow cytometry , pathology , pharmacology , immunology , inflammation , central nervous system , biology , ecology , psychiatry
Neuropathic pain causes great distress among patients; however, its response to traditional analgesia techniques remains sub-optimal. There has been progress in stem cell research for neuropathic pain treatment; however, effective homing remains problematic. This study aimed to establish Fe 3 O 4 @polydopamine(PDA)-labeled mesenchymal stem cells (MSCs); moreover, we aimed to guide MSCs using a magnetic field to the spinal cord segments showing pain-related responses to allow MSC homing and gathering, in advance, in order to fully employ their repair function.