Open AccessPeptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin
Author(s) -
Enrico Gallo,
Carlo Diaferia,
Elisabetta Rosa,
Giovanni Smaldone,
Giancarlo Morelli,
Antonella Accardo
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s296272
Subject(s) - self healing hydrogels , doxorubicin , cytotoxicity , viability assay , peptide , drug delivery , nanogel , chemistry , dynamic light scattering , biophysics , materials science , in vitro , biochemistry , nanoparticle , nanotechnology , medicine , organic chemistry , chemotherapy , surgery , biology
The clinical use of the antitumoral drug doxorubicin (Dox) is reduced by its dose-limiting toxicity, related to cardiotoxic side effects and myelosuppression. In order to overcome these drawbacks, here we describe the synthesis, the structural characterization and the in vitro cytotoxicity assays of hydrogels (HGs) and nanogels (NGs) based on short peptide sequences loaded with Dox or with its liposomal formulation, Doxil.