Open AccessDoxorubicin (DOX) Gadolinium–Gold-Complex: A New Way to Tune Hybrid Nanorods as Theranostic Agent
Author(s) -
Memona Khan,
Sarah Boumati,
Célia Arib,
Amadou Thierno Diallo,
Nadia Djaker,
BichThuy Doan,
Jolanda Spadavecchia
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s295809
Subject(s) - doxorubicin , materials science , biocompatibility , nanorod , nanoparticle , photothermal therapy , colloidal gold , nuclear chemistry , gadolinium , drug delivery , nanotechnology , pegylation , polyethylene glycol , chemistry , organic chemistry , medicine , surgery , chemotherapy , metallurgy
In this paper, we have designed and formulated, a novel synthesis of doxorubicin (DOX) loaded bimetallic gold nanorods in which gold salt (HAuCl 4 ) is chelated with anthracycline (DOX), diacid polyethylene-glycol (PEG-COOH) and gadolinium salt (GdCl 3 * 6 H 2 O) to form DOX IN-Gd-AuNRs compared with DOX ON-Gd-AuNRs in which the drug was grafted onto the bimetallic pegylated nanoparticle surface by electrostatic adsorption.