Open AccessAptamer-Targeted Calcium Phosphosilicate Nanoparticles for Effective Imaging of Pancreatic and Prostate Cancer
Author(s) -
Thomas Abraham,
Christopher McGovern,
Samuel S. Linton,
Zachary R. Wilczynski,
James H. Adair,
Gail L. Matters
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s295740
Subject(s) - aptamer , indocyanine green , in vivo , ex vivo , pancreas , pancreatic cancer , pancreatic tumor , prostate cancer , cancer research , prostate , chemistry , cancer , pathology , medicine , microbiology and biotechnology , biology
Accurate tumor identification and staging can be difficult. Aptamer-targeted indocyanine green (ICG)-nanoparticles can enhance near-infrared fluorescent imaging of pancreatic and prostate tumors and could improve early cancer detection. This project explored whether calcium-phosphosilicate nanoparticles, also known as NanoJackets (NJs), that were bioconjugated with a tumor-specific targeting DNA aptamer could improve the non-invasive detection of pancreatic and prostate tumors.