Open AccessRosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage
Author(s) -
Liu Zi,
Wencheng Zhou,
Jiake Xu,
Junshu Li,
Ning Li,
Jianguo Xu,
Chao You,
Chengwei Wang,
Meng Tian
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s294916
Subject(s) - neuroinflammation , proinflammatory cytokine , intracerebral hemorrhage , materials science , in vivo , rosuvastatin , pharmacology , zeta potential , microglia , medicine , biophysics , inflammation , immunology , nanotechnology , nanoparticle , biology , microbiology and biotechnology , subarachnoid hemorrhage
Intracerebral hemorrhage (ICH), a devastating subtype of stroke, has a poor prognosis. However, there is no effective therapy currently available due to its complex pathological progression, in which neuroinflammation plays a pivotal role in secondary brain injury. In this work, the use of statin-loaded nanomicelles to target the neuroinflammation and improve the efficacy was studied in a mouse model of ICH.