Open AccessA Selenium Nanocomposite Protects the Mouse Brain from Oxidative Injury Following Intracerebral Hemorrhage
Author(s) -
Yong Yang,
Guoying Deng,
Peng Wang,
Guangzhao Lv,
Rui Mao,
Yuhao Sun,
Baofeng Wang,
Xijian Liu,
Liuguan Bian,
Dong Zhou
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s293681
Subject(s) - oxidative stress , neuroprotection , reactive oxygen species , pharmacology , intracerebral hemorrhage , blood–brain barrier , apoptosis , edaravone , medicine , chemistry , anesthesia , biochemistry , subarachnoid hemorrhage , central nervous system
Intracerebral hemorrhage (ICH) is a common neurological crisis leading to high mortality and morbidity. Oxidative stress-induced secondary injury plays a critical role in neurological deterioration. Previously, we synthesized a porous Se@SiO 2 nanocomposite and identified their therapeutic role in osteonecrosis of the femoral head. Whether this nanocomposite is neuroprotective remains to be elucidated.